Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study Atorvastatina no Tiene Efectos sobre los Tejidos Renales de Ratas Wistar Albinas en el Consumo a Largo Plazo: Un Estudio de Microscopia Electr車nica

作者：Ayfer Aktas; M Serhan Tasdemir; M Cudi Tuncer; Yusuf Nergiz

来源：International Journal of Morphology, 2011.

• Ri on
• Ratas Wistar albinas
• Estatinas
• Atorvastatina
• Ultraestructurales
• Kidney
• Wistar-albino rat
• Statins
• Atorvastatin
• Ultrastructural

In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200-250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite increasing the dose of atorvastatin intake, the histological structures of atorvastatin groups were appeared normal in the same period. In conclusion, long-term use of atorvastatin was not found to have an adverse effect on kidney tissue. En un modelo de rata, se evaluaron los hallazgos ultraestructurales del ri 車n provocados por la administraci車n sist谷mica de diferentes dosis de atorvastatina. Las estatinas pueden tener efectos anti-inflamatorios que desempe an un importante rol en la prevenci車n del da o celular. El objetivo de este estudio fue investigar c車mo la atorvastatina podr赤a desempe ar un papel en los tejidos del ri 車n. 40 Ratas Wistar albinas Adultas (200-250 g) machos fueron divididas aleatoriamente en cuatro grupos de 10 ejemplares cada uno (A1, A2, A3 y Control). Tres diferentes dosis de atorvastatina se utilizaron para determinar los efectos sobre los tejidos del ri 車n durante un per赤odo de 90 d赤as. Los ri ones de los grupos A1 (0,1 mg), A2 (0,5 mg) y A3 (1 mg) fueron extirpados a los 90 d赤as y los tejidos examinados por microscop赤a electr車nica de transmisi車n. A pesar de haberse aumentado la dosis de ingesta de atorvastatina, las estructuras histol車gicas se asemejaron al grupo normal del mismo per赤odo. En conclusi車n, el uso de atorvastatina en un plazo prolongado, no produce efecto negativo sobre el tejido renal.