科研之友
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摘要
Objective To study the effects of propofol on oxyradical and TXA in the asthmatic rats.Methods Twenty-eight Wistar rats were divided randomly into four groups:control group,asthma group,low dose propofol group and high dose propofol group.The rats in asthma group were sensitized by injection of ovalbumin,2 weeks later followed aerosolized ovalbumin challenge.The animals of propofol group were sensitized as asthma group,but were injected intravenously withpropofol(50 mg·kg~(-1)·h~(-1) and 75 mg·kg~(-1)·h~(-1)) for half hour after the last challenge.Fifteen min later,the contents of MDA and TXB_2 in plasma and lung tissues were m-easured.Results The expression of MDA and TXB2 were higher than those of control group( P<0.01).After pretreated with propofol,the MDA levels and TXB_2 in plasma were significantly lower than those of asthma group.But there was no significance between different dose of propofol groups(P >0.05).Conclusion Propofol can enhance anti-oxidation activity,reduce the reaction of lipid-peroxidation and reduce the releasing of TXB_2.
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