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摘要
The infectious diseases caused by pathogenic microorganisms seriously threaten human public safety, especially the multi-drug resistant bacteria (MDR). Antimicrobial peptides (AMPs) have attracted much attention because their non-drug resistance or lower drug resistance for bacteria with the advantages of good thermal stability, high antimicrobial activity, high specificity and few mammalian cytotoxic side effects. AMPs have the physiological functions of active defense and immunity, and are expected to be ideal antibiotic substitutes. AMPs possess single or synergistic bacteriostasis effect on cells with multiple targets, and thus they are of great significance to clarify the antibacterial mechanism with multiple targets for the application of AMPs. In this paper, the antibacterial mechanism of AMPs was systematically reviewed from the perspectives of multiple targets including cell wall damage, cell membrane damage, the mechanisms of intracellular biomacromolecule synthesis, the mechanisms of material and energy metabolism affecting key enzymes activity, and the mechanisms of mitochondrial injury and immunoregulation. The antibacterial mechanism of AMPs was prospected to provide theoretical reference for antibacterial mechanism of AMPs. ? 2022 Editorial office of Journal of Food Science and Biotechnology.
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