摘要

泛素化是蛋白质翻译后调控的重要途径。作为体内最大的E3泛素连接酶家族,Cullin-Ring类E3泛素连接酶广泛参与调控机体内细胞周期蛋白和转录因子的降解。其中,CUL2作为骨架分子形成CUL2泛素连接酶复合物,在希佩尔-林道(von Hippel-Lindau,VHL)肿瘤抑制因子相关受体底物的泛素化降解中发挥重要的作用。目前,研究发现CUL2普遍参与肿瘤血管生成、细胞动力、免疫逃逸、细胞增殖及等肿瘤恶变机制的调控。综述CUL2在肿瘤发生中的作用机制及其与宫颈癌的关系,旨在为宫颈癌的诊断和治疗提供新的作用靶点。

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