Iridium‐Catalyzed Regio‐ and Enantioselective Borylation of Unbiased Methylene C(sp3)?H Bonds at the Position β to a Nitrogen Center

作者：Du Rongrong; Liu Luhua; Xu Senmiao

来源：Angewandte Chemie, 2021, 133(11): 5907-5911.

DOI：10.1002/ange.202016009

• asymmetric catalysis
• C?H borylation
• chiral amines
• organoboron compounds
• pyrazoles

Reported herein is the pyrazole‐directed iridium‐catalyzed enantioselective borylation of unbiased methylene C?H bonds at the position β to a nitrogen center. The combination of a chiral bidentate boryl ligand, iridium precursor, and pyrazole directing group was responsible for the high regio‐ and enantioselectivity observed. The method tolerated a vast array of functional groups to afford the corresponding C(sp3)?H functionalization products with good to excellent enantioselectivity.

• 单位
  羰基合成与选择氧化国家重点实验室; 杭州师范大学; 中国科学院大学