科研之友
微信
新浪微博
Facebook
分享链接
摘要
<正>The CRISPR/Cas system is a very powerful and versatile tool for genomic manipulation.A recent study published in Cell Research by Wu et al.[1]reported a Cas9-mediated strategy to correct a disease-causing mutation in the mouse gamma C-crystallin(Crygc)locus in spermatogonial stem cells(SSCs)to cure the resulting cataracts disease in the offspring with 100%efficiency.Importantly,no off-target mutations were identified through whole-genome sequencing.
