Stereoselective Total Synthesis of (3 S ,5 S )‐1,7‐Bis(4‐hydroxyphenyl)heptane‐3,5‐diol, (3 S ,5 S )‐Alpinikatin, and Its Diastereoisomers

作者：Kunuru Venkatesham; Sudina Purushotham Reddy; Baggu Chinnababu; Katragadda Suresh Babu

来源：Helvetica Chimica Acta, 2015, 98(9): 1307-1314.

DOI：10.1002/hlca.201500073

• Diarylheptanoids
• Brown 's allylation
• Et2Zn‐mediated alkynylation

Abstract(#br)Stereoselective synthesis of the diarylheptanoids, (3 S ,5 S )‐1,7‐bis(4‐hydroxyphenyl)heptane‐3,5‐diol ( 1 ), (3 S ,5 S )‐alpinikatin ( 3 ), and their diastereoisomers ( 2 and 4 , resp.), was achieved from readily available 4‐hydroxybenzaldehyde. The synthetic sequences involve Browns ...