Estado oxidante/antioxidante total em rec谷m-nascidos ict谷ricos antes e depois da fototerapia

作者：Aycicek; Ali; Erel; Ozcan

来源：Jornal de Pediatria, 2007.

DOI：10.1590/S0021-75572007000500006

• antioxidants
• infant
• malondialdehyde
• oxidative stress
• phototherapy.

objective: to assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns. method: thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. the serum antioxidant status was assessed by measuring the total antioxidant capacity (tac) and individual antioxidant components: vitamin c, uric acid, albumin, thiol contents and total bilirubin. the oxidant status was assessed by determining the total oxidant status (tos), oxidative stress index (osi) and individual oxidant components: malondialdehyde (mda), and lipid hydroperoxide levels. results: vitamin c, uric acid, total bilirubin and mda concentration were significantly lower, whereas serum tos, lipid hydroperoxide and osi levels were significantly higher after phototherapy (p %26lt; 0.05). there were significant positive correlations between serum total bilirubin and mda (r = 0.434, p = 0.001). conclusions: although the mda level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.