科研之友
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摘要
objectives: to assess the prevalence of respiratory disease in school-aged children and to determine the value of field spirometry. methods: data on 313 1st and 4th graders from four public schools in lisbon were analyzed. a respiratory self-answered questionnaire and standard spirometry were performed. descriptive and bivariate analysis was followed by multiple logistic regression. results: thirty-five percent of the children presented at least one episode of wheezing (18% %26gt; 2 episodes), and 4% had asthma. wheezing was more frequent with family history of atopy (adjusted or = 2.7; 95%ci 1.4-5.1), maternal smoking during pregnancy, lower respiratory tract infection (lrti) (adjusted or = 2.8; 95%ci 1.2-6.2), bronchiolitis (adjusted or = 3.3; 95%ci 1.3-8.2), and allergy to aeroallergens (adjusted or = 3.2; 95%ci 1.4-7.2). asthma was more frequent with previous history of lrti (adjusted or = 14.6; 95%ci 1.7-122.9) and allergy to aeroallergens (adjusted or = 8.2; 95%ci 2.0-34.2). fifty-five percent of spirometry measurements met the acceptability criteria of the american thoracic society and of the european respiratory society. wheezers presented mean lower z scores for forced expiratory volume in 1 second (fev1), ratio between fev1 and forced vital capacity (fvc) (fev1/fvc), and forced expiratory flow between 25 and 75% (fef25-75) (p %26lt; 0.05), as well as higher percentage of abnormal fev1, fev1/fvc and fef25-75 (fef25-75, p %26lt; 0.05). conclusions: this pilot study showed a high prevalence of obstructive airway symptoms in school-aged children in lisbon. symptoms assessed by the questionnaire showed good correlation with spirometric values. the small prevalence of asthma leads us to speculate that asthma is under-diagnosed in this population.
