The Hybrid of Cu―TCPP@Mn₃O₄ for Inflammation Relief by ROS Scavenging and O₂ Production: An Efficient Strategy for Antiviral Therapy

作者：Chen, Liu-Rong; Zou, Yi-Ming; Li, Rong-Tian; Zhou, Xuan; Lai, Ye-Hua; Chen, Jin-Xiang; Yang, Jie^*

来源：Small, 2024, 20(10).

DOI：10.1002/smll.202306095

• antiviral drug
• influenza treatment
• metal-organic frameworks
• nanomedicine

Seasonal influenza still greatly threatens public health worldwide, leading to significant morbidity and mortality. Antiviral medications for influenza treatment are limited and accompanied by increased drug resistance. In severe influenza virus infection, hyperinflammation and hypoxia may be the significant threats associated with mortality, so the development of effective therapeutic methods to alleviate excessive inflammation while reducing viral damage is highly pursued. Here, a multifunctional MOF-based nanohybrid of CuTCPP@Mn3O4 as a novel drug against influenza A virus infection (MOF = metal-organic framework; TCPP = tetrakis (4-carboxyphenyl) porphyrin) is designed. CuTCPP@Mn3O4 exhibits potent inhibitory capability against influenza A virus infection in vitro and in vivo. The mechanism study reveals that CuTCPP@Mn3O4 inhibits the virus entry by binding to the HA2 subunit of influenza A virus hemagglutinin. In addition, the nanoparticles of Mn3O4 in CuTCPP@Mn3O4 can scavenge intracellular ROS with O(2 )generation to downregulate inflammatory factors and effectively inhibit cytokines production. By reconstructing the antioxidant microenvironment, CuTCPP@Mn3O4 features as a promising nanomedicine with anti-inflammatory and anti-viral synergistic effects.

• 单位
  东莞市人民医院; 南方医科大学