Prote赤na C-reativa ultra-sens赤vel em pacientes com diagn車stico de doenˋa arterial coronariana estabelecido por angiografia

作者：Lima; Luciana Moreira; Carvalho; Maria das Graas; Loures Vale; Andreia Assis; Fonseca Neto; Cirilo Pereira da; Garcia; Jose Carlos de Faria; Saad; Jamil Abdala; Sousa; Marinez Oliveira

来源：Jornal Brasileiro de Patologia e Medicina Laboratorial, 2007.

DOI：10.1590/S1676-24442007000200003

• coronary angiography
• coronary artery disease
• high-sensitivity c-reactive protein.

c-reactive protein (cpr) is an acute phase protein, synthesized by the liver in response to cytokines, and reflects active inflammation. inflammation has a potential role in atherosclerosis triggering and progression. plasma markers of chronic inflammation have been consistently associated to the risk of coronary artery disease (cad), being high-sensitivity c-reactive protein the marker most studied. the aim of the present study was to determine the high-sensitivity c-reactive protein plasma levels in a group of subjects undergoing coronary angiography, trying to establish a possible correlation between this parameter and the severity of the cad. high-sensitivity c-reactive protein plasma levels had been determined in blood of 17 subjects with no atheromatosis (controls), 12 subjects presenting mild/moderate atheromatosis and 28 subjects presenting severe atheromatosis, using biotechnical reactive c-protein turbidimetric kit with specific high-sensitivity methodology for cardiology, with linearity to 0.1 up 15mg/l. significant differences between the means of the three groups were not observed, however the mean values of mild/moderate atheromatosis and severe atheromatosis had remained above the reference values used in cardiology (0.1-2.5mg/dl). the mean values of the three groups presented an increasing rise from the control group to the severe atherosclerosis, suggesting inflammatory progression due to atherosclerotic injury.