中药有效成分抗皮肤光老化作用及其机制研究进展

作者：Ding Miao-Miao; Wei Ling; Chen Chun-Yu; Chen Jia-Ping; Liu Chang-Xiao; He Xin^*

来源：China Journal of Chinese Materia Medica, 2022, 47(14): 3709-3717.

DOI：10.19540/j.cnki.cjcmm.20220415.601

• Active ingredients of Chinese medicine
• Matrix metalloproteinase
• Oxidative stress
• Skin photoaging
• Ultraviolet

Skin photoaging is exogenous aging caused by long-term ultraviolet radiation, which not only affects skin appearance, but also has a close relationship with the development of skin cancer. Saponins, flavonoids, polyphenols, polysaccharides, and extracts of Chinese medicine have been found to have anti-skin photoaging effects in recent studies. Various mechanisms such as anti-oxidative stress damage, inhibition of matrix metalloproteinase expression, promotion of collagen synthesis, inhibition of inflammatory response, DNA damage repair, enhancement of cell autophagy, and inhibition of melanin synthesis can improve the symptoms of skin photoaging and delay the photoaging process. With the active ingredients of Chinese medicine for anti-skin photoaging as the entry point, the study systematically discussed the research progress of the mechanisms underlying the anti-photoaging effects of active ingredients of Chinese medicine in recent years, in order to provide theoretical reference for the development of new anti-photoaging drugs and methods. ? 2022, Editorial Board of China Journal of Chinese Materia Medica. All right reserved.

• 单位
  北京协和医学院; 中国医学科学院北京协和医院; 天然药物活性物质与功能国家重点实验室