科研之友
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摘要
Background: One of the most important strategies in research and development of new anticancer agents is the tumor-specific induction of apoptosis. The effects of semisynthetic derivative of vitamin E, (汐-TOS, D-汐-tocopheryl succinate), appear to be largely restricted to malignant cells. Methods: We investigated the in vivo effects of intraperitoneally administered 汐-TOS on vitality of Ehrlich ascites carcinoma cells (EAC) in mice, as well as the influence of 汐-TOS on specific activity of enzymes involved in antioxidative mechanisms in EAC cells. Results: According to our results, the intraperitoneal application of 汐-TOS induces the decrease of the EAC vitality, and the statistically significant alteration of the glutathione-dependent enzyme activity in EAC cells. Conclusion: We may conclude that 汐-TOS is an important micronutrient, with significant impact on vitality and metabolism of malignant cells.
