N-acetil-汕-D-glicosaminidase como biomarcador precoce de disfunˋˋo renal para a exposiˋˋo ocupacional ao chumbo inorganico

作者：Gonales; Leandro Nishikawa; Paoliello; Mnica Maria Bastos; Janeiro; Vanderly; Machinski Junior; Miguel

来源：Jornal Brasileiro de Patologia e Medicina Laboratorial, 2008.

DOI：10.1590/S1676-24442008000400003

• lead
• n-acetyl-&beta
• -d-glucosaminidase
• biomarker
• occupational health
• urine.

objective: this study aimed to verify the enzymatic activity of n-acetyl-汕-d-glucosaminidase (nag) as a possible early biomarker of renal dysfunction due to occupational exposure to inorganic lead. materials and methods: we selected a group of 30 males that had been exposed to inorganic lead in a battery factory in the state of paran芍. this group comprised those employees whose blood lead levels were below 40 mg/dl. the control group consisted of 15 healthy adults of similar age and gender compared with the exposed group. blood lead concentrations, d-aminolevulinic acid levels and urinary nag activity were measured. results and discussion: it was shown that urinary nag activity was significantly higher (p %26lt; 0.05, u test of mann-whitney) in the exposed group in comparison to the control group, and there was a significant negative correlation (p %26lt; 0.05, spearman rank order correlation) between the biological indicator of lead exposure and urinary nag activity. conclusion: the results showed that the increase of urinary nag activity may be used as an early biomarker of the exposure to inorganic lead.