维生素B族复合TRP肽和SOD对焦虑性抑郁症C57BL/6小鼠行为学改善的影响

作者：Zhu Xi-Ping; Li Wen-Zhi; Tao Qian; He Wen-Jiang; Cui Chun^*

来源：食品与机械, 2020, 36(3): 166-172.

DOI：10.13652/j.issn.1003-5788.2020.03.032

• anxious depression
• inflammatory factors
• oxidative stress
• trp metabolism
• Vitamin B

Investigated effects of vitamin B complex TRP peptides and SOD on the anti-oxidative activity in brain tissue, serum inflammatory factor levels and reverse anxious/depression-like behaviors. Vitamin B complex TRP peptide and SOD (VB3 : VB6 : TRP peptide: SOD = 2: 10: 3: 4; VBPS) high, medium and low gavage doses were 260, 195, 130 mg/(kg ? d), respectively. Studies showed that VBPS could reverse the anxious/depression-like behaviors and the slow body weight gain, with VBPS at a high dose being more effective. VBPS showed to control the effects of serum inflammatory cytokines (TNF-α, IL-6, IL-1β and IFN-γ), decrease malondialdehyde (MDA) levels and increase superoxide dismutase (SOD), catalase (CAT), nitric oxide synthase (NOS) activity. In addition, VBPS induced down-regulation of TRP-KYN metabolism and up-regulation of KYN-NAD+ metabolism. In summary, results from animal experiments showed that VBPS had a significant anti-anxious depression effects as evidenced by anti-inflammatory, anti-oxidation, reversed behavioral dysfunctions and bodyweight of mice treated with VBPS compared to the anxious depression control mice. It is proved that consume VBPS diets can induce significant beneficial effects on anxious depression. ? 2020 Editorial Department of Food and Machinery, shipin yu jixie.

• 单位
  华南理工大学