Syntheses, Crystal Structures and DNA-Binding Properties of Zn(Ⅱ) and Mn(Ⅱ) Complexes Based on Imidazole Derivatives and Carboxylic Acid

作者：关慧超; 宋晓彤; 刘贵宝; 岳淑美^*

来源：Chinese Journal of Structural Chemistry, 2022, 41(03): 260-269.

DOI：10.14102/j.cnki.0254-5861.2011-3363

Complexes [Zn(pbm)(5-hip)3](1), [Zn(pbm)(5-nip)3](2), [Mn(pbm)(H3 btc)2(H2O)](3) and [Mn(pbm)(5-nip)3](4), where H2HIPA = 5-hydroxyisophthalic acid, H2nip= 5-nitroisophthalic acid, H3btc = trimesic acid and pbm(pyridine benzene chelate material) = 2-(2-pyridyl)benzimidazole, were identified via single-crystal XRD analyses. 1, 2 and 4 pertain to the monoclinic space group C2/c, while 3 belongs to the triclinic space group ■. The interplay of CT-DNA with those complexes was delineated using ultraviolet, fluorescence, and circular dichroism(CD) spectroscopy and viscosity measurements. Complexes 1, 2, 3 and 4 interact with CT-DNA in an electrostatic or grooving mode. We wish to offer a theory-wise foundation for developing anti-tumor medicines.