“CALM”让CAR-T细胞疗法更强大（英文）

作者：梅恒; Parameswaran Hari; 胡豫^*

来源：Science Bulletin, 2022, 67(19): 1925-1928.

• CAR-T
• 细胞疗法

<正>Chimeric antigen receptor (CAR)-T therapy was first described in 1989 and has revolutionized the management of hematological cancers with its great potential in reinforcing T cells against tumors[1]. CAR-T therapies are mechanistically different from more traditional approaches to the treatment of hematological cancers such as surgery, chemoradiotherapy, and monoclonal antibody therapy.To date, six CAR-T products have been approved by the US Food and Drug Administration (FDA) and successfully applied to the treatment of B-cell acute lymphoblastic leukemia (B-ALL), diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL),

• 单位
  华中科技大学