Synthesis of S-monofluoromethyl phosphorothioates from PⅤ-H compounds and PhSO2SCH2F

作者：Renyi Pang; Ruichao Yao; Shiyao Lu; Yicheng Zhou; Wenbo Chen^*

来源：Chinese Chemical Letters, 2021, 32(01): 453-456.

S-Monofluoromethyl phosphorothioates represent an important class of organofluorine compounds and are re ported here for the first time.A series of S-monofluoromethyl phosphorothioates are conveniently synthesized from different Pv-H compounds and PhSO2 SCH2 F under mild conditions.The method is compatible with common functional groups and provides potential opportunities to synthesize new bioactive molecules for medicinal chemistry.

• 单位
  上海大学; 中国科学院