抗血小板药物治疗与肠息肉内镜切除术后出血的相关性研究

作者：Li Huan; Wu Qingming; Long Hui^*

来源：中华消化内镜杂志, 2020, 37(10): 727-731.

DOI：10.3760/cma.j.cn321463-20190504-00320

• Antiplatelet agents therapy
• Endoscopic resection
• Intestinal polyps
• Postoperative hemorrhage

Objective To investigate if antiplatelet agents increase postoperative bleeding risk in patients receiving endoscopic resection of intestinal polyps. Methods Data of 539 patients who received endoscopic polypectomy from January 2015 to December 2017 in Tianyou Hospital were collected in this retrospective study. Patients were divided into two groups, including antiplatelet therapy group (n = 88), which consisted of aspirin-treated subgroup (n = 59) and clopidogrel-treated subgroup (n = 29), and non-antiplatelet therapy group (n = 451). The bleeding incidences after endoscopic polypectomy were compared among groups by Chi-square test. Results The postoperative bleeding incidence in all 539 patients was 3. 0% (16 / 539). And the incidences in the antiplatelet groups and the non-antiplatelet group were 3. 4% (3 / 88) and 2. 9% (13 / 451), respectively (P > 0. 05). Also, there was no statistical difference in the aspirin-treated subgroup (3. 4%, 2 / 59), clopidogrel-treated subgroup (3. 4%, 1 / 29) and non-antiplatelet treated group in the incidence of postoperative bleeding (χ2 = 0. 561, P = 0. 642). Conclusion Antiplatelet agents including aspirin or clopidogrel may not increase the postoperative bleeding risk in patients receiving endoscopic resection of intestinal polyps. ? 2020 Chinese Journal of Digestive Endoscopy.

• 单位
  武汉科技大学