High Concentration of Reticular Fibers in Periurethral Region of the Prostatic Urethra from Patients with Benign Prostatic Hyperplasia as Revealed by Stereology Alta Concentraci車n de Fibras Reticulares en la Regi車n Periuretral de la Uretra Prost芍tica de Pacientes con Hiperplasia Prost芍tica Benigna Revelada por Estereolog赤a

作者：Jorge H M Manaia; Waldemar S Costa; Francisco J B Sampaio; Marcelo A Figueiredo

来源：International Journal of Morphology, 2012.

• Uretra prostatica
• Fibras reticulares
• Estereologia
• Prostatic urethra
• Reticular fibers
• Stereology

The goal of this investigation was to analyze and quantify changes of the reticular fibers in the prostatic urethra of patients with benign prostatic hyperplasia (BPH) and compare with a control group. Prostatic urethra tissue samples were obtained from ten patients (age range 65 to 79 years, mean 66) with clinical symptoms of bladder outlet obstruction who had undergone open prostatectomy. The ten control group samples (urethral tissue samples from the transitional zone) were collected from prostates obtained during autopsy of accidental death adults of less than 25 years. The Vv of the reticular fibers was determined with stereologic methods from 25 random fields per sample using the point-count method with a M-42 grid test system. The quantitative data were analyzed using the Kolmogorov-Smirnov and Mann-Whitney U tests. The Vv (mean㊣SD) in the control and BPH groups respectively were: 23.4㊣ 1.8 and 30.3 ㊣ 1.2 (0.001). BPH cause significant increase of reticular fibers in prostatic urethra. El objetivo de esta investigaci車n fue analizar y cuantificar los cambios de las fibras reticulares en la uretra prost芍tica de pacientes con hiperplasia prost芍tica benigna (HPB) y compararlo con un grupo control. Muestras de tejido de uretra prost芍tica se obtuvieron de diez pacientes (rango de edad 65 a 79 a os, media 66) con s赤ntomas cl赤nicos de obstrucci車n del tracto urinario inferior que se hab赤an sometido a prostatectom赤a abierta. Las diez muestras del grupo de control (muestras uretrales de tejido de la zona de transici車n) se obtuvieron de pr車statas durante la autopsia de sujetos adultos con muerte accidental menores de 25 a os. El Vv de las fibras reticulares se determin車 con m谷todos estereol車gicos de 25 campos al azar por muestra utilizando el m谷todo de valor de conteo con el sistema M-42. Los datos cuantitativos se analizaron mediante la prueba de Kolmogorov-Smirnov y Mann-Whitney U. El Vv (media ㊣ DE) en el grupo control y BPH, respectivamente, fueron: 23,4 ㊣ 1,8 y 30,3 ㊣ 1,2 (0,001). La BPH caus車 aumento significativo de fibras reticulares en uretra prost芍tica.