Ru(Ⅲ)-catalyzed construction of variously substituted quinolines from 2-aminoaromatic aldehydes(ketones) and isoxazoles: Isoxazoles as cyclization reagent and cyano sources

作者：Di Hu; Chao Pi^*; Wei Hu; Xiliang Han; Yangjie Wu; Xiuling Cui^*

来源：Chinese Chemical Letters, 2022, 33(08): 4064-4068.

A Ru(Ⅲ)-catalyzed annulation reaction of 2-aminoaromatic aldehydes(ketones) and isoxazoles to afford diverse 3-cyanoquinolines has been developed. Notably, isoxazole acted as a cyclization reagent and nontoxic cyano source via N-O bond cleavage and fragmentation. Variously substituted(especially 6-or 7-substituted) quinolines could be easily afforded. This procedure features wide functional group compatibility, efficiency and avoiding toxic cyano source. Meanwhile, this protocol could be successfully applied to scale-up synthesis. Further chemical transformations of 3-cyanoquinoline could give some valuable skeletons, demonstrating its potential in synthetic application

• 单位
  郑州大学