科研之友
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摘要
we describe the case of a 67 year -old female with nephrotic syndrome and rapidly progressive renal failure. the nephropaty was characterized by deposits of randomly oriented fibrils with a diameter of about 18-20 nm on electron microscopy. immunofluorescence microscopy was performed and there was no staining for immunoglobulins and complement. we diagnosed atypical fibrillary glomerulopathy with absence of immune deposits. the patient developed end-stage renal failure rapidly. we review in the literature new clinical and pathogenetic features related to fibrillary and immunotactoid glomerulopathy.
