Novel targets for sensitizing breast cancer cells to TRAIL‐induced apoptosis with siRNA delivery

作者：Bindu Thapa; Remant Bahadur KC; Hasan Uluda

来源：International Journal of Cancer, 2018, 142(3): 597-606.

DOI：10.1002/ijc.31079

• apoptosis
• breast cancer
• tumor necrosis factor‐related apoptosis‐inducing ligand
• siRNA library

Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel reg...

• 单位
  The University of Alberta; university of alberta