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摘要
Objective: To observe the value of left ventricular pressure-strain loop (LV-PSL) for evaluating the degree of coronary artery disease in patients with coronary heart disease (CHD). Methods: Totally 154 CHD patients were enrolled and divided into mild group (n=51), moderate group (n=53) and severe group (n=50) according to Gensini scores, and 50 healthy volunteers were taken as controls (control group). The left ventricular global longitudinal strain (GLS) and myocardial work (MW) parameters, including global constructive work (GCW), global wasted work (GWW), global work index (GWI) and global work efficiency (GWE) were observed and compared with LV-PSL among groups, and the efficacy for evaluating the degree of coronary artery disease was analyzed. Results: There were significant differences of GLS and MW parameters among groups (all P<0.05). In mild group, GWW was higher, while GWE was lower than those in control group (both P<0.05). In moderate group, GWW was higher, while GLS, GWI, GCW and GWE were lower than those in mild group and control group (all P<0.05). GWW in severe group was higher, while GLS, GWI, GCW and GWE were lower than those in the other 3 groups (all P<0.05). The area under the curve of GWE for evaluating moderate and severe coronary artery lesions in CHD patients was greater than that of GWI, GCW and GWW (Z=0.73, 0.74, 0.88, all P<0.001). Taken 94.50% as the best cutoff value of GWE, the specificity was 87.00% and the sensitivity was 83.00%. Gensini score was moderately and positively correlated with GWW (r=0.69, P<0.01), lowly negatively correlated with GWI and GCW (r=-0.42, -0.43, both P<0.01), and moderately negatively correlated with GWE (r=-0.79, P<0.01). Conclusion: LV-PSL had certain value for evaluating the degree of coronary artery disease in CHD patients, and left ventricular GWE had the best diagnostic efficacy.
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