科研之友
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摘要
background: high-sensitivity c-reactive protein (hs-crp) is an established risk predictor in primary prevention. among available laboratory methods, enzyme linked immunosorbent assay (elisa) and nephelometry are the most validated for this clinical application. immunoluminometry is another high-sensitivity method of hs-crp, with definitive prognostic value in acute coronary syndromes. however, it lacks validation for cardiovascular risk prediction in the outpatient setting, whose hs-crp values are in a lower range in relation to unstable patients. objective: in an outpatient setting, test the hypothesis that the immunoluminometric method has enough accuracy to measure hs-crp and classify individuals according to cardiovascular risk. method: c-reactive protein was measured by the methods of immunoluminometry and nephelometry in 152 serum samples obtained from different outpatient subjects. taken nephelometry as a gold-standard, performance of the immunoluminometric method was evaluated. results: there was a strong linear association between the two methods, according to the correlation coefficient (r = 0.996; p 3mg/l) - kappa = 0.96; p %26lt; 0.001. conclusion: the immunoluminometric method of hs-crp represents an alternative to nephelometry for the assessment of cardiovascular risk in an outpatient population.
