Synthesis, structure characterization and preliminary biological evaluation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

作者：Xie Yong Sheng; Pan Xiao Hong; Zhao Bao Xiang^*; Liu Jin Ting; Shin Dong Soo; Zhang Jin Hua; Zheng Liang Wen; Zhao Jing; Miao Jun Ying

来源：Journal of Organometallic Chemistry, 2008, 693(7): 1367-1374.

DOI：10.1016/j.jorganchem.2008.01.043

• ferrocene
• pyrazole-fused pyrazinone
• synthesis
• X-ray structure
• bioactivity
• A549 cell

A series of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives were synthesized by the reaction of ethyl 1-(2-bromoethyl)-3-ferrocenyl-1H-pyrazole-5-carboxylate with non-aromatic primary amines in one-pot procedure and characterized by (1)H NMR, (13)C NMR, IR, HRMS and X-ray diffraction analysis. The effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had almost inhibitory effects on the growth of A549 cells.

• 单位
  山东大学