Nonpeptidic Selective Inhibitors of the Chymotrypsin‐Like (β5 i) Subunit of the Immunoproteasome

作者：Dr IzidorSosi; Dr MartinaGobec; Dr BorisBrus; DamijanKnez; Dr Matejivec; Dr JanezKonc; SamoLenik; MitjaOgrizek; Prof Dr AleObreza; Dr Duanigon; Prof Dr DuankaJanei; Prof Dr IrenaMlinari‐Raan; Prof Dr StanislavGobec

来源：Angewandte Chemie, 2016, 128(19): 5839-5842.

DOI：10.1002/ange.201600190

• Immunproteasom
• Inhibitoren
• Irreversible Inhibierung
• Niedermolekulare Inhibitoren
• Wirkstoffentwicklung

Abstract(#br)Elevated expression of the immunoproteasome has been associated with autoimmune diseases, inflammatory diseases, and various types of cancer. Selective inhibitors of the immunoproteasome are not only scarce, but also almost entirely restricted to peptide‐based compounds. Herein, we desc...