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摘要
Objective: To analyze and compare the parameters of red blood cell (RBC) and iron metabolism in the children with cancer related anemia of chronic disease (CRA-ACD) and cancer related iron-deficiency anemia (CRA - IDA), in order to make clear the features of two kinds of anemia and the significance of the parameters of iron metabolisms and RBC in the differential diagnosis. M ethods: A total of 14 cases of CRA - IDA and 16 cases of CRA - ACD were selected, and another 20 healthy children were enrolled into the control group. The RBC parameters (M CV, M CH, and M CHC) and iron metabolism parameters (SI, TIBC, TS, and SF) were detected and compared between the three groups. Results: M CV in CRA - IDA group ([77. 53± 6. 78] fL) and CRA - ACD group ([80. 12± 4. 83] fL) was smaller than that in control group ([90. 01± 2. 90] fL) (P< 0. 01). M CH, M CHC, SI, TS, and TIBC in CRA - IDA group and CRA - ACD group were lower than in control group (P < 0. 01). SF in CRA - IDA group and CRA - ACD group was higher than that in control group (P < 0. 01), but the above parameters showed no significance difference between CRA - IDA group and CRA - ACD group (P> 0. 05). The abnormal rates of M CV, SI, TS, and TIBC were similar in the two groups (P> 0. 05). SF value of 7 cases in CRA - IDA group and 11 cases in CRA - ACD group were higher than 200 μg/L (P< 0. 05). None of the CRA - ACD group had an SF level lower than 30 μg/L, and only 5 cases of CRA - IDA group were found with low SF level (P> 0. 05). Conclusion: The clinical manifestations of CRA - IDA and CRA - ACD are similar in this study. Red blood cell parameters such as M CV, SI, TS, and TIBC could not be simply used to analyze the etiology of CRA, and novel biological indicators should be found to identify the CRA-IDA and CRA-ACD. ? 2023 Editorial Board of Medical Journal of Wuhan University.
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