科研之友
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摘要
objective: to assess the role of transforming growth factor-汕1 (tgf-汕1) in congenital ureteropelvic junction obstruction at diagnosis and during postoperative follow-up. material and methods: we conducted a case-control study including 19 patients with a mean age of 6.7 years and 19 matched controls. all patients presented negative voiding cystourethrography, obstructive diuretic renogram and underwent dismembered pyeloplasty. urinary tgf-汕1 and other markers were measured pre-, intra- and postoperatively. results: the mean bladder urine tgf-汕1 concentration in obstructed patients prior to pyeloplasty was higher than in controls (92.5 pg/ml ㊣ 16.8 vs. 35.8 pg/ml ㊣ 16.2; p = 0.0001). the mean renal pelvic urine tgf-汕1 concentration in the hydronephrotic kidney was higher than in the preoperative bladder urine sample (122.3 pg/ml ㊣ 43.9 vs. 92.5 pg/ml ㊣ 16.8; p = 0.036). postoperative mean tgf-汕1 concentration was significantly lower than preoperative tgf-汕1 (48.7 pg/ml ㊣ 13.1 vs. 92.5 pg/ml ㊣ 16.8; p = 0.0001). conclusion: tgf-汕1 is a cytokine leading to renal fibrosis. the measurement of urinary tgf-汕1 could become a useful tool for the diagnosis of obstructive hydronephrosis and the evaluation of the parenchyma function status, pre and postoperatively.
