Back Cover: PD‐L1 Aptamer‐Functionalized Metal–Organic Framework Nanoparticles for Robust Photo‐Immunotherapy against Cancer with Enhanced Safety (Angew. Chem. Int. Ed. 5/2023)

作者：Zhang Jingfang; Li Wenzhe; Qi Yafei; Wang Guorong; Li Lele; Jin Zhengyu; Tian Jie; Du Yang

来源：Angewandte Chemie - International Edition, 2023, 62(5).

DOI：10.1002/anie.202218931

• DNA Nanotechnology
• Immunotherapy
• Metal–Organic Frameworks
• PD-L1 Aptamer
• Spherical Nucleic Acids (SNAs)

PD‐L1 aptamer‐based spherical nucleic acids (SNAs) were designed that consist of oxaliplatin (OXA) encapsulated in a metal–organic framework (MOF) nanoparticle core and a dense shell of PD‐L1 aptamer (denoted as M@O‐A), as reported by Zhengyu Jin, Jie Tian, Yang Du, and co‐workers in their Research Article (e202214750). Upon light irradiation, the versatile M@O‐A allows for robust photo‐immunotherapy against cancer by combining photodynamic therapy, chemotherapy, and immunotherapy in one nanoplatform with reduced immunotoxicity.

• 单位
  中国医学科学院北京协和医院; 北京协和医学院; 天然药物与仿生药物国家重点实验室; 复杂系统管理与控制国家重点实验室; 中国科学院; 北京大学