Synthesis and Crystal Structure of a Ca~Ⅱ Coordination Polymer of H_2Adefovir (H_2Adefovir={[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl}phosphonic Acid)

作者：LOU Ben Yong a b LIN Qi a a b

来源：结构化学, 2011, (07): 1059-1063.

• Adefovir
• coordination polymer
• phosphate

A Ca II coordination polymer of H 2 Adefovir (H 2 Adefovir={[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid),[Ca(H 2 O)(Adefovir)] n (1),has been synthesized via the reaction of Ca(OH) 2 and H 2 Adefovir under hydrothermal conditions.Complex 1 crystallizes in the monoclinic system,space group P2 1 /c with a=22.344(5),b=6.8505(14),c=8.0101(17),β=90.356(4)o,V=1226.0(4)3,M r=329.28,D c=1.784 g/cm 3,μ=0.672 mm-1,F(000)=680,Z=4,the final R=0.0296 and wR=0.0916 for 2295 observed reflections with I > 2σ(I).In the structure,the Ca II center is coordinated to the phosphate group of Adefovir anion,forming a 2D coordination layer,and such layers are linked into a 3D framework by hydrogen-bonding interactions between the adenine groups of Adefovir anion.