摘要

Many researchers have advocated in recent times that antiseptic use in healing wounds should be discouraged. Antiseptics have been found to retard healing of wounds. Innocuous solutions like normal saline and tap water are being considered as better alternatives to antiseptics. Chlorhexidine, a commonly used antiseptic, is known to be less toxic on granulation cells. We decided to compare the effect of chlorhexidine, normal saline and tap water on healing wounds. Three groups of wistar rats had 2 by 2cm full thickness wounds made on their right dorsolateral flanks. The wounds were dressed with either chlorhexidine, normal saline or tap water. Wounds were examined at three-day intervals and measurements of area covered were taken on the first day of study and the ninth day. Wound contraction on the ninth day and number of days for healing to take place in the different groups was taken and statistical analysis using student t-test was done to compare the values. Gross morphology of the wounds was also observed. The result showed an inhibitory effect of chlorhexidine on healing wounds. The wound contraction in the antiseptic group was less than the tap water and saline group on day nine. The average number of days for wound healing to be completed in the antiseptic group was more than the other two. These results were statistically significant when compared with the other two groups. There was no statistical difference in the wound contraction values and rate of healing of the saline and tap water dressed wounds. Grossly, all the wounds dressed with antiseptic also had greenish exudates on their surface by day nine with pale looking granulation tissue, and there was greater mortality in this group En la actualidad, diversos investigadores han propagado que el uso de antis谷pticos en heridas en cicatrizaci車n deber赤a, ser abandonado. Se ha encontrado que los antis谷pticos retardan la cicatrizaci車n. Soluciones inocuas, tales como, suero salino y agua corriente, est芍n siendo consideradas como mejores alternativas para efectos antis谷pticos. La clorhexidina, un antis谷ptico com迆nmente usado, es conocida por ser menos t車xica sobre las c谷lulas granulares. Basado en lo anterior, comparamos los efectos de la clorhexidina, suero salino y agua corriente en heridas en cicatrizaci車n. A tres grupos de ratas Wistar se les infiri車 heridas de 2 x 2 cm de grosor, en su flanco dorsolateral derecho. La heridas fueron cubiertas (pinceladas) con clorhexidina, soluci車n salina o agua corriente, seg迆n el caso. Estas heridas fueronn examinadas cada tres d赤as y las mediciones del 芍rea c

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