科研之友
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摘要
purpose: to evaluate the fio2 effect at 0,21, 0,40 and 1,00 on the lung ischaemia-reperfusion injury. methods: forty wistar rats were randomly allocated in 4 groups. the group i was the control one, and in groups ii, iii, iv rats were ventilated during the ischaemia-reperfusion at 0,21, 0,40 and 1.00 fio2 respectively. the ischaemia time was 30 minutes and the reperfusion time was 10 minutes. the model used was normothermic ischaemia-reperfusion, in situ. as assessment parameters, the systemic average arterial pressure (pam), the oxygen arterial partial pressure/ inspired oxygen fraction relation (po2/fio2), the level of reduced glutathione (gsh) and barbituric acid substances reactive measure (tbars) in the lung tissue and the lung wet/dry weight ratio were used. results: the results showed that the ventilation with fio2 at 0,21, when compared with the ventilation at 0,40 and 1,00 fio2 during the ischaemia-reperfusion period, presented lower pam, better po2/fio2 relation, higher values in the reduced glutathione measures, lower production of the tbars and lower formation of lung edema. conclusion: the ventilation with low fio2 (0.21) showed better results when compared to those performed with higher fio2 (0,40 and 1,00) on the lung ischaemia-reperfusion injury.
