摘要

目的:分析脓毒性休克新生儿临床特点及影响其预后的相关因素。方法:选取2019年1月—2020年6月期间在湛江市妇幼保健院接受诊治的60例脓毒性休克新生儿为研究对象,所有患儿均送往新生儿重症监护病房(NICU)进行相关治疗,统计记录患儿临床资料,采用相关统计学方法分析脓毒性休克新生儿预后结果的影响因素。结果:60例脓毒性休克新生儿发病症状统计。反应差51例,发热、发绀32例,呼吸抑制39例,其它10例。病原菌检出结果:革兰氏阳性菌19例,革兰氏阴性菌11例,真菌21例,其它9例。早发型脓毒症37例,晚发型脓毒症23例,预后病亡7例。两组患儿胎龄、性别、NICU住院时长及白细胞计数对比,差异无统计学意义(P>0.05)。两组患儿器官功能障碍数量、机械通气时长、PCT及乳酸对比,差异有统计学意义(t/χ2=27.202、27.463、15.903、17.111,P<0.05)。logistic多因素回归分析显示,器官功能障碍数量>3个、机械通气时间≥2 d、PCT>10 ng/L、乳酸≥3 mmol/L是脓毒性休克新生儿预后病亡独立危险因素。结论:器官功能障碍数>3个、机械通气时间≥2 d、PCT>10 ng/L、乳酸≥3 mmol/L是脓毒性休克新生儿预后病亡独立危险因素。

  • 单位
    湛江市妇幼保健院
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