An芍lise da freq邦那ncia de trombofilia em pacientes com atrofia branca de Milian

作者：Jorge; Aline Donati; Fantini; Bruno de Carvalho; Rivitti; Evandro A; Benabou; Joseph E; Vasconcellos; Cidia; Criado; Paulo Ricardo

来源：Anais Brasileiros de Dermatologia, 2007.

DOI：10.1590/S0365-05962007000100003

• antiphospholipid syndrome
• antithrombin iii
• atrophy
• blood vessels
• leg ulcer
• skin diseases
• vascular
• thrombophilia
• thrombophilia [etiology]
• thrombosis
• vasculitis.

introduction: atrophie blanche, or livedoid vasculopathy, is a rare clinicopathological entity of unknown etiology. a %26quot;thrombo-occlusive process%26quot; theory has recently been accepted. objectives: to search the presence of several thrombophilic abnormalities in patients with livedoid vasculopathy. methods: fourteen patients were evaluated and tested for factor v leiden, prothrombin 20210g/a variant, antithrombin, c and s proteins, anticardiolipin and lupus anticoagulant antibodies, homocysteine and methylenetetrahydrofolate reductase mutation. results: nine patients met all criteria to be included in the analysis and four of them had a thrombophilic state: antithrombin deficiency (one case), protein s deficiency (one case), methylenetetrahydrofolate reductase mutation with hyperhomocysteinemia (one case) and presence of anticardiolipin antibodies (one case). conclusions: although this tendency cannot be statistically proven, thrombophilic abnormalities seem to be more frequent in patients with atrophie blanche, indicating that screening for thrombophilia of all patients with livedoid vasculopathy might be recommended.