科研之友
微信
新浪微博
Facebook
分享链接
摘要
Objective: To observe effect of percutaneous transluminal angioplasty (PTA) with drug coated balloon for treatment of lower extremity atherosclerotic occlusive disease (LEAOD). Methods: Totally 43 LEAOD patients (43 lower limbs) were randomly divided into study group (n=21) and control group (n=22). Patients in study group were treated with drug-coated balloon PTA, and those in control group with general balloon. Fontaine stages before and 7 days after PTA were counted in both groups. The internal diameter, restenosis rate and ankle-brachial index (ABI) of the target artery segment of superficial femoral artery were calculated before PTA and 1, 3, 6 months after PTA, while stenosis rate of the target artery segment of superficial femoral artery was counted at 6 months after PTA. Results: Fontaine stage 7 days after PTA were lower in both groups than that before PTA (both P<0.05). One month, 3 and 6 months after PTA, the internal diameter of the target artery segment of superficial femoral artery in study group were larger than that in control group (all P<0.05), while the restenosis rate were lower than that in control group (all P<0.05). Three and 6 months after PTA, ABI of study group were larger than that of control group (both P<0.05). Six month after PTA, the stenosis rate of target artery segment superficial femoral artery in study group were <30% in 14 cases, 30%-50% in 4 cases, >50% in 3 cases (no 100%) while in control group were <30% in 2 cases, 30%-50% in 10 cases, >50% in 10 cases (100% in 2 cases) (P<0.01). Conclusion: PTA with drug coated balloon is safe and effective in treatment of LEAOD, which can reduce the rate of restenosis, and the short-term effect is better than that PTA with ordinary balloon.
