Spheroids from adipose‐derived stem cells exhibit an miRNA profile of highly undifferentiated cells

作者:A Barbara Di Stefano PhD; Federica Grisafi MSc; Marta Castiglia PhD; Alessandro Perez PhD; Luigi Montesano MD; Alessandro Gulino PhD; Francesca Toia MD; Daniele F****e PhD; Antonio Russo MD; Francesco Moschella MD; Angelo A Leto Barone MD; Adriana Cordova MD
来源:Journal of Cellular Physiology, 2018, 233(11): 8778-8789.
DOI:10.1002/jcp.26785

摘要

Two‐dimensional (2D) cell cultures have been extensively used to investigate stem cell biology, but new insights show that the 2D model may not properly represent the potential of the tissue of origin. Conversely, three‐dimensional cultures exhibit protein expression patterns and intercellular junct...