重构Hippo信号通路分子网络（英文）

作者：钟振兴; 孟志鹏; 余发星^*

来源：Science Bulletin, 2023, 68(20): 2307-2310.

<正>The mechanism by which organs perceive their size and regulate growth in accordance remains enigmatic.The Hippo signaling pathway has been recognized as a master regulator for organ size,tissue regeneration,and tumorigenesis [1,2].In the last two decades or so,major components of the Hippo pathway have been uncovered,primarily in Drosophila and occasionally in mammals.A comprehensive understanding of the molecular framework and regulatory mechanisms of the Hippo pathway holds immense potential for advancements in cancer therapies and regenerative medicine.

• 单位
  复旦大学; 遗传工程国家重点实验室