科研之友
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摘要
blockade of tumor necrosis factor with monoclonal antibodies, has emerged as one of the most promising therapies in some autoimmune conditions as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and crohn%26apos;s disease. they have shown effectiveness on reducing symptoms and modifying the progression of the disease. however, they disrupt the balance of inflammatory and immune responses and some risks associated with tnf-blockers have become apparent. the purpose of this article is to review the evidence about benefits and risk associated with the use of tnf-blockers in approved indications and to provide practical recommendations for its use in the management of this conditions.
