科研之友
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摘要
Functional constipation(FC) is a disease with a high prevalence commonly encountered in clinical settings,which can seriously impair human physical and mental health.This article reviews the latest progress in the diagnosis and treatment of FC. It mainly includes that the exact etiology and pathogenesis of FC are not yet clear. The diagnosis of FC mainly depends on the symptoms of patients, and constipation caused by intestinal and systemic organic causes should be excluded.Clinical examination methods for FC usually include colorectal transit time measurement,anorectal manometry,balloon expulsion test,defecography and dynamic MRI defecography.The treatments mainly include general management,pharmacotherapy,biofeedback therapy,traditional Chinese medicine treatment,psychological treatment and surgical management.Pharmacotherapy plays a greater role in treating FC than other therapies.Surgical management is only used for those with very serious conditions and without response to medical treatment.Moreover,indicators for surgical intervention should be strictly assessed.Although the surgical intervention can be performed based on individual conditions,the incidence of postoperative complications is high.At the same time, this paper also introduces some new FC therapies which have been gradually applied in clinic in recent years, such as ssacral neuromodulation and fecal bacteria transplantation,and some clinical effects have been achieved. Therefore, this article aims to provide new ideas for the future treatment of FC.
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