Copper-Catalyzed Electrophilic Arylation of Isatoic Anhydride with Diaryliodonium Salts for Synthesis of N-Phenylated Isatoic Anhydrides

作者：Wu, Xi-Xi; He, Yonghui; Zhao, Xiao-Jing^*; Li, Ganpeng^*

来源：Asian Journal of Organic Chemistry, 2022, 11(7): e202200155.

DOI：10.1002/ajoc.202200155

• copper-catalyzed
• diaryliodonium salts
• electrophilic arylation
• mild conditions
• N-Phenylated isatoic anhydrides

A copper-catalyzed N-arylation of various isatoic anhydrides with diaryliodonium salts was developed by using inexpensive CuI as the catalyst under mild conditions. The method provides diverse N-Phenylated isatoic anhydrides in high yields (up to 97%). The mechanism of the N-arylation reaction is proposed to involve an electrophilic addition process.

• 单位
  云南民族大学