科研之友
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摘要
The current experiment was aimed to investigate the effects of dietary supplemented with different levels of magnolol on growth performance, liver antioxidant function and lipid metabolism of weaned piglets. One hundred and forty-four 21-day-old healthy "Duroc×Landrace×Large White" crossbred barrows with similar body weight of (7.91±0.00) kg were randomly divided into 3 groups with 8 replicates per group and 6 pigs per replicate. Piglets in the 3 groups were fed a basal diet (control group), the basal diet+0. 02% honokiol (0.02% honokiol group), and the basal diet+0.04% honokiol (0.04% honokiol group) . The experiment lasted for 35 days after 7 days of adaption. The results showed as follows: 1) compared with the control group, dietary supplemented with 0.04% magnolol significantly increased the average daily gain (ADG) of piglets at days 1 to 19 and days 20 to 35, and significantly decreased the ratio of feed to gain (F / G) at days 1 to 19 and days 20 to 35 (P<0. 05) . The diarrhea rate and diarrhea index of piglets in the 0. 02% magnolol group and 0.04% magnolol group were significantly lower than those in the control group (P<0.05) . 2) Compared with the control group, dietary supplemented with 0.04% magnolol significantly increased the activities of glutathione peroxidase (GSH-Px), total superoxide dismutase (T-SOD) and catalase (CAT) in liver of weaned piglets (P<0.05) . 3) Compared with the control group, dietary supplemented with 0.04% magnolol significantly or extremely significantly increased the mRNA relative expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (Keap1), CAT, superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), and glutathione S-transferase (GST) in liver of weaned piglets (P<0.05 or P<0.01) . 4) Compared with the control group, dietary supplemented with 0.04% magnolol significantly decreased the contents of cholesterol and high-density lipoprotein in liver of weaned piglets (P<0.05) . 5) Compared with the control group, dietary supplemented with 0.04% magnolol significantly decreased the mRNA relative expression levels of fatty acid synthetase (FAS) and adipose triglyceride lipase (ATGL) in liver of weaned piglets (P<0.05) . In conclusion, dietary supplemented with 0.04% magnolol can improve the antioxidant capacity, improve lipid metabolism, and then protect normal physiological function of liver, finally the growth performance of weaned piglets is improved.
