New Cytochalasins from the Marine‐Derived Fungus Xylaria sp. SCSIO 156

作者：Ziming Chen; Hongbo Huang; Yuchan Chen; Zhongwen Wang; Junying Ma; Bo Wang; Weimin Zhang; Changsheng Zhang; Jianhua Ju

来源：Helvetica Chimica Acta, 2011, 94(9): 1671-1676.

DOI：10.1002/hlca.201100051

<jats:title>Abstract</jats:title><jats:p>Two new cytochalasins, 18‐deoxycytochalasin Q (<jats:bold>1</jats:bold>) and 21‐<jats:italic>O</jats:italic>‐deacetylcytochalasin Q (<jats:bold>2</jats:bold>), together with four known analogues, cytochalasin Q (<jats:bold>3</jats:bold>), 19,20‐epoxycytochalasin Q (<jats:bold>4</jats:bold>), 21‐<jats:italic>O</jats:italic>‐deacetyl‐19,20‐epoxycytochalasin Q (<jats:bold>5</jats:bold>), and cytochalasin D (<jats:bold>6</jats:bold>), were isolated from the fungus <jats:italic>Xylaria</jats:italic> sp. SCSIO156 originated from the South China Sea marine sediment. The structures of <jats:bold>1</jats:bold> and <jats:bold>2</jats:bold> were elucidated by MS and 1D‐ and 2D‐NMR data analyses, and comparison with known compounds. The known compounds <jats:bold>3</jats:bold>–<jats:bold>6</jats:bold> were identified by comparison of their MS and NMR data with those reported in the literature. In the <jats:italic>in vitro</jats:italic> antitumor assay, compounds <jats:bold>2</jats:bold>–<jats:bold>6</jats:bold> showed mild cytotoxicity against three tumor cell lines (MCF‐7, SF‐268, and NCI‐H460).</jats:p>

• 单位
  中国科学院; 中国科学院大学; 广东省微生物研究所