FDG uptake level of bone marrow and spleen with clinicopathological features in non-small cell lung cancer patients [骨髓、脾脏FDG摄取水平与非小细胞肺癌临床病理特征]

作者：Zhuo Y.; Sun J.^*; Ma Y.; He Z.

来源：Chinese Journal of Medical Imaging Technology, 2023, 39(2): 216-221.

DOI：10.13929/j.issn.1003-3289.2023.02.014

• bone marrow
• carcinoma
• fluorodeoxyglucose F18
• mononuclear phagocyte system
• non-small-cell lung
• positron-emission tomography
• spleen
• tomography
• X-ray computed

Objective To explore the relationships of FDG uptake level of bone marrow and spleen on 18 F-FDG PET/CT with clinicopathological features in patients with non-small cell lung cancer (NSCLC). Methods Totally 82 NSCLC patients who underwent preoperative 18F-FDG PET/CT examination (NSCLC group) and 41 non-tumor patients (control group) were enrolled. The levels of FDG uptake in bone marrow and spleen were compared between groups,and the relationships of FDG uptake and clinicopathological features were analyzed. Results The mean standard uptake value (SUVmean) of bone marrow,bone marrow to liver uptake ratio (BLR), as well as spleen to liver uptake ratio (SLR) in NSCLC group were all higher than those in control group (all P<0. 05). NSCLC patients who were male,with squamous cell carcinoma, high TNM stage,tumor size〉3 cm and local lymph node metastases had higher primary focus maximum standard uptake value (SUVmax) (all P<0. 05). Patients with higher TNM stage,tumor size〉3 cm and local lymph node metastases had higher bone marrow SUVmeanand BLR (all P<C0. 05),with higher TNM stage and tumor size >3 cm had higher SLR (both P<0. 05). Splenic SUVmeanwas only associated with TNM stage (P<0. 05). Conclusion High FDG uptake of bone marrow and spleen in NSCLC patients were related to the clinicopathological features of tumor reflecting poor prognosis.