A Red‐Light‐Activated Ruthenium‐Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells

作者：Lucien N Lameijer; Danil Ernst; Dr Samantha L Hopkins; Michael S Meijer; Dr Sven H C Askes; Dr Sylvia E Le Dévédec; Dr Sylvestre Bonnet

来源：Angewandte Chemie, 2017, 129(38): 11707-11711.

DOI：10.1002/ange.201703890

• Hypoxie
• Photopharmakologie
• Rotlichtaktivierung
• Ruthenium
• Tumortherapeutika

Abstract(#br)We describe two water‐soluble ruthenium complexes, [ 1 ]Cl2 and [ 2 ]Cl2, that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm?2) of red light in an oxygen‐independent manner. Using...