科研之友
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摘要
Background: A number of studies have shown that obesity, overweight and dyslipidemia have various strength of correlation with diabetes, but there is a lack of longitudinal studies to verify this issue. Objective: To perform a longitudinal study of diabetes prevalence, and the strength of correlationof body mass index(BMI) and blood lipid with diabetes in an older health check-up population of Luzhou during 2016 to 2019, providing a scientific basis for the formulation of diabetes prevention and treatment strategies for the elderly. Methods: A longitude study design was used. Health check-up data of Luzhou older adults(≥64 years old) in four consecutive years(from 2016 to 2019) were retrospectively collected, including gender, age, BMI, smoking and alcohol consumption, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). Generalized estimating equation was used to analyze the strength of correlation of BMI, TC, TG, LDL-C and HDL-C with diabetes. Results: The prevalence of diabetes in the participants during 2016-2019 was 10.5%(15 893/151 132), 11.5% (17 375/151 132), 11.9%(18 019/151 132) and 13.5% (20 394/151 132), respectively. After controlling for gender, age, smoking and alcohol consumption, the analysis using generalized estimating equation revealed that obesity〔OR=2.610, 95%CI (2.523, 2.700)〕, overweight〔OR=1.749, 95%CI (1.710, 1.790)〕, increased TC〔OR=1.073, 95%CI(1.040, 1.106)〕, marginally increased TG〔OR=1.151, 95%CI (1.126, 1.177)〕, increased TG〔OR=2.091, 95%CI (2.042, 2.140)〕, marginally increased LDL-C〔OR=1.208, 95%CI (1.178, 1.240)〕, increased LDL-C〔OR=1.264, 95%CI (1.219, 1.310)〕, and decreased HDL-C〔OR=1.552, 95%CI (1.506, 1.599)〕 were correlated with increased risk of diabetes (P<0.01). Slightly underweight〔OR=0.763, 95%CI (0.73, 0.798)〕 and marginally increased TC 〔OR=0.868, 95%CI (0.850, 0.886)〕were correlated with decreased risk of diabetes (P<0.01). Conclusion: The prevalence of diabetes was relatively high in the elderlyhealth check-up population of Sichuan's Luzhou, which may be closely correlated with overweight / obesity and dyslipidemia. In view of this, it is suggested to lose weight and lower blood lipids to reduce diabetes prevalence and to prevent diabetes in this group.
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