科研之友
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Background: Hemoglobin glycation index(HGI)is a simple marker of hemoglobin glycation, which is closely related to various chronic complications, such as diabetic microvasculopathy and macroavasculopathy. However, there are few studies on the relationship between HGI and hyperuricemia(HUA)in type 2 diabetes mellitus (T2DM). Objective: To investigate the predictive value of HGI for HUA in T2DM. Methods: Eligible participants were T2DM patients(n=1 194)who received treatment and personal health record creation services from Department of Endocrinology, the Affiliated Hospital of Southwest Medical University between January 2017 and January 2021. Demographics, physical examination information, laboratory test markers and calculated HGI were collected. HUA prevalence was compared across tertile groups of HGI〔low HGI(< -0.94%), moderate HGI(-0.94%≤HGI< 0.27%), and high HGI(HGI≥0.27%)〕. Multivariate Logistic regression analysis was used to explore the factors affecting the development of HUA in T2DM. The receiver operating characteristic(ROC)curve was plotted for HGI with clinical markers in predicting HUA in T2DM. Results: Low HGI group had much lower prevalence of HUA than did moderate HGI group 〔17.09%(68/398)vs 27.14%(108/398), χ2=11.672, P< 0.01〕 and high HGI group 〔17.09%(68/398)vs 31.66%(126/398), χ2=22.928, P< 0.01〕. Multivariate Logistic regression analysis found that age〔OR=1.048, 95%CI(1.029, 1.067)〕, subcutaneous fat area(SFA)〔OR=1.006, 95%CI(1.001, 1.010)〕, triglyceride(TG)〔OR=1.096, 95%CI(1.034, 1.161)〕, high density lipid-cholesterol(HDL-C)〔OR=0.560, 95%CI(0.326, 0.961)〕, and HGI 〔OR=1.360, 95%CI(1.208, 1.531)〕 independently influenced the development of HUA in T2DM(P< 0.05). After adjusting for age, SFA, TG, and HDL-C, it was found that the risk of HUA was 1.855 times higher in moderate HGI group 〔95%CI(1.283, 2.681), P< 0.001〕, and 2.192 times higher in high HGI group 〔95%CI(1.530, 3.141), P< 0.001〕 compared to that of low HGI group. The AUC for HGI with clinical markers〔Logit(P)=-4.549+0.618×moderate HGI+0.785×high HGI+0.039×age+0.008×SFA+0.088×TG-0.750×HDL-C〕 to diagnose HUA in T2DM was 0.71〔95%CI(0.68, 0.75)〕, with sensitivity of 78.7%, specificity of 53.5%, Youden index of 0.322, and optimal cut-off value of 0.208. Conclusion: T2DM patients with elevated HGI may be more prone to HUA. HGI could be used as a clinical predictor of HUA in T2DM.
