Efic芍cia e seguranˋa de dois inaladores de p車 seco usados para a aplicaˋˋo de furoato de mometasona em pacientes com asma

作者：Pereira; Carlos Alberto de Castro; Vianna; Flavia Fillardo; Cukier; Alberto; Stelmach; Rafael; Oliveira; Julio Cesar Abreu de; Carvalho; Erich Vidal; Gomes; Edimar Pedrosa; Mayo; Suzete Varela; Chibante; Antnio Monteiro da Silva; Domingues; Claudia Patricia

来源：Jornal Brasileiro de Pneumologia, 2010.

DOI：10.1590/S1806-37132010000400004

• anti-asthmatic agents
• pregnadienediols
• metered dose inhalers.

objective: mometasone furoate (mf) is a new, potent synthetic inhaled corticosteroid. worldwide, mf is administered via a dry-powder inhaler that contains multiple doses. as a preparation that would be more cost-effective, single-dose mf capsules were developed in brazil. the objective of the present study was to evaluate the efficacy and safety of the two inhalers for mf administration in patients with asthma. methods: a randomized, multicenter, open-label, parallel-group clinical trial involving 74 adult patients with moderate, persistent asthma who were randomized into two groups to receive approximately 400 米g of mf once a day for 60 days, either via the multiple-dose inhaler or via the newly developed single-dose inhaler. results: no significant differences were observed between the two groups regarding the primary endpoints (fev1 and rescue medication use) or the secondary endpoints (morning pef, tolerability, and safety, the last as assessed on the basis of hypothalamic-pituitary-adrenal axis function). conclusions: the use of the single-dose inhaler developed in brazil for mf administration is as effective and safe as is that of a standard inhaler in the treatment of patients with asthma.