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摘要
Objective: Potassium dichromate (K2Cr2O7) is a potent pollutant for human and animal health. The purpose of the current work is to compare the effect of K2Cr2O7 using variations in the dose, route of administration and duration of exposure in male and female Wistar albino rats and to research the interaction of chromium and selenium with a special focus on hematopoiesis. Materials and methods: K2Cr2O7 was subcutaneously administered alone (10, 50 and 100 mg/kg body weight) or K2Cr2O7 (10 mg/kg) in association with selenium (0.3 mg/kg) was administered to female Wistar albino rats. Male rats received in their drinking water K2Cr2O7 (30 mg/L/day) alone or in association with Se (0.3 mg/L/day) for 20 consecutive days. The hematological parameters were evaluated on days 3, 6 and 21 after subcutaneous (sc.) treatment in female rats and on days 10 and 20 after oral administration in male rats. Results: K2Cr2O7 induced during the first three days a significant (p %26lt; 0.05) dose-dependent decrease in the number of erythrocytes, platelets, leucocytes, lymphocytes and the hematocrit levels, and a dose-dependent increase in the number of granulocytes and monocytes. In the drinking water, chromium sc. significantly decreased the number of leucocytes and lymphocytes on day 10 after treatment and elevated the number of granulocytes and monocytes 20 days later. Selenium sc. counterbalanced the hematotoxic effects of chromium in female rats. Conclusion: These results suggest that the selenium has a protective role against the hematotoxicity of subcutaneous chromium in female Wistar rats. Objectif : Le dichromate de potassium (K2Cr2O7) est un polluant potentiellement n谷faste pour la sant谷 humaine et animale. Cette 谷tude a 谷t谷 entreprise afin de rechercher une 谷ventuelle interaction entre le K2Cr2O7 et le s谷l谷nium (Se) sur l＊h谷matopo 豕se chez les rats albinos Wistar males et femelles. Mat谷riel et M谷thodes : Le K2Cr2O7 est administr谷 seul (10, 50 et 100 mg/kg) par voie sous-cutan谷e (sc) ou en association (10 mg/kg) avec le s谷l谷nium (0,3 mg/kg). Les rats males re oivent dans l＊eau de boisson le K2Cr2O7 (30 mg/L/jour) seul ou en association avec le s谷l谷nium (0,3 mg/L/jour) pendant 20 jours cons谷cutifs. Les variations des param豕tres h谷matologiques sont 谷valu谷es au 3e, 6e et 21e jour chez les rattes et au 10e et 20e jour chez les males. R谷sultats : Les r谷sultats montrent que le chrome engendre d豕s le 3e jour apr豕s son administration par voie sc chez la femelle une diminution notable et dose-d谷pendante (p %26lt; 0,05) du nombre d＊谷rythrocytes, du taux d＊h谷matocrite, du nombre de pla
