Green Catalyst- and Additive-Free Three-Component Deamination Cyclization Synthesis of 3-Substituted-4-oxo-2-quinazolinonyl Sulfides

作者：Zheng, Lvyin^*; Xie, Zhen; Cai, Liuhuan; Liu, Gongping; Mei, Weijie; Zou, Xiaoying; Zhuo, Xiaoya; Fan, Xiaolin; Guo, Wei^*

来源：ChemistrySelect, 2021, 6(42): 11768-11774.

DOI：10.1002/slct.202103747

• Green synthesis
• Deamination cyclization
• Catalyst- free
• Additive-free
• 3-Substituted-4-oxo-2-quinazolinonyl sulfides

An efficient three-component deamination annulation of 2-aminobenzamides, isothiocyanates and alkyl bromides for the synthesis of valuable 3-substituted-4-oxo-2-quinazolinonyl sulfides is reported. The reaction proceeds in the absence of any external catalysts and additives. The facile process has the advantages of broad substrate scopes, mild reaction conditions and environmental friendliness, which might provide the synthetic applications for 3-substituted-4-oxo-2-quinazolinonyl sulfides as potential anti-cancer agents in medicinal chemistry.

• 单位
  赣南师范大学