摘要
An efficient three-component deamination annulation of 2-aminobenzamides, isothiocyanates and alkyl bromides for the synthesis of valuable 3-substituted-4-oxo-2-quinazolinonyl sulfides is reported. The reaction proceeds in the absence of any external catalysts and additives. The facile process has the advantages of broad substrate scopes, mild reaction conditions and environmental friendliness, which might provide the synthetic applications for 3-substituted-4-oxo-2-quinazolinonyl sulfides as potential anti-cancer agents in medicinal chemistry.
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